Research & Training

Research Innovation

Our research mission is to uncover the fundamental biological mechanisms of health and disease and translate those discoveries into new therapies. As Canada's largest institute of its kind, the LSI leads in addressing medicine's greatest challenges and improving health outcomes.

Our Labs

At the LSI, our faculty members are recognized as some of Canada's top researchers, receiving prestigious awards at the institutional, provincial, and national levels. Discover cutting-edge research by exploring our labs, with options to search and filter by topic or department.

Recent Publications

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A selfish supergene causes meiotic drive through both sexes in Drosophila

Researcher: Wei

Advances in Cell Replacement Therapies for Diabetes

Researcher: Kieffer

Within-host competition causes pathogen molecular evolution and perpetual microbiota dysbiosis

Researcher: King

Fate and state transitions during human blood vessel organoid development

Researcher: Penninger

Clinical translation of microbiome research

Researcher: Tropini

Escape from X-chromosome inactivation at KDM5C is driven by promoter-proximal DNA elements and enhanced by domain context

Researcher: Brown

Multimodal cell maps as a foundation for structural and functional genomics

Researcher: Foster

Western red cedar (Thuja plicata) beehives have no impact on honey bee (Apis mellifera) overwintering colony survival or detoxification enzyme expression

Researcher: Foster

Red Blood Cells with Reduced Deformability are Selectively Cleared from Circulation in a Mouse Model

Researcher: Ma

Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH

Researcher: Strynadka

ABO blood group and COVID-19 severity: Associations with endothelial and adipocyte activation in critically ill patients

Researcher: Conway

From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants

Researcher: Jean

A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration

Researcher: Tanentzapf

Honey bee egg composition changes seasonally and after acute maternal virus infection

Researcher: Foster

Retinal gene therapy for Stargardt disease with dual AAV intein vectors is both safe and effective in large animal models

Researcher: Molday