Ongoing Projects
Type I IFN response to Mycobacterium tuberculosis Infection
Investigating how Type I IFN-stimulated genes (ISGs) influence the host response to Mycobacterium tuberculosis infection. Using gene knockouts and overexpression models in macrophages, to assess bacterial burden, immune signaling, and host cell responses to determine whether specific ISGs contribute to bacterial clearance or disease progression. A wide array of techniques, such as flow cytometry, high-content imaging, and bacterial reporter assays, is employed to uncover novel host-directed therapeutic strategies for tuberculosis.