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    Yip Lab

    Research Focus Teams: Cancer, Rare Diseases

    Lab Team

    Dr. Calvin Yip
    Calvin Yip

    Professor

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    CONTACT

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    Samples in the lab being handled.
    Alex Shaw

    PhD Student

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    Alice Liu

    Honours Thesis Student

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    Chase Talarico

    MSc Student

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    Chloe House

    MSc Student

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    Elijah Hoy

    PhD Student

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    Hannah Shariati

    PhD Student

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    Kelly Ye

    Work Learn Student

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    Kha Nguyen

    PhD Student

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    Rachel Wang

    Directed Studies Student

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    Sunny Cheung

    Postdoctoral Fellow, Yip Lab

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    Tomas Pelletier

    PhD Student

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    Ongoing Projects

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    Autophagy machinery

    How does a cell remove and recycle unwanted materials? Autophagy is an evolutionarily conserved pathway that encapsulates large objects to be degraded in a double-membrane vesicle called the autophagosome and targets this cargo to the lysosome for breakdown. Defects in this pathway have been implicated in neurodegenerative disorders, cancers, and other human diseases. We study how a specialized group of proteins that mediate the different steps of this important degradative pathway using biochemical, structural biology, and cell biology approaches.
    Autophagy machinery

    Chromatin modifying complexes

    How does a cell establishes and maintains its gene expression pattern and adapts this to different environmental conditions? Eukaryotic genomic DNA exists in a DNA-protein complex known as chromatin. Post translational modifications to the histone proteins that form the nucleosome, the most basic unit of chromatin, is a key mechanism to regulate chromatin structure and gene expression. Using budding yeast as a model, we study how specialized multi-protein chromatin modifying complexes in this organism perform their physiological functions using biochemical and structural biology approaches.
    Chromatin modifying complexes

    Rare genetic diseases

    There are over 7,000 different types of rare diseases. It is estimated that 1 in 12 Canadians is affected by a rare disease. Although the genetic bases of many of these diseases have been uncovered, the molecular mechanism of how these genetic changes lead to severe clinical phenotypes remains undefined. We are applying biochemical, structural, and cell biology approaches to address this problem, with an emphasis on the severe multi-system disorder Vici syndrome (https://vicisyndrome.org).
    Rare genetic diseases