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    Teves Lab

    Research Focus Teams: Cancer, Cardiovascular Disease

    Lab Team

    Dr. Sheila Teves
    Sheila Teves

    Assistant Professor

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    CONTACT

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    Alexander Wong

    Masters Student

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    Hazel Cui

    PhD Candidate

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    Henry Young

    Masters Student

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    Samples in the lab being handled.
    Krystal Tan

    Masters Student

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    Rachel Price

    PhD candidate

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    Ongoing Projects

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    Mechanisms of Transcription Initiation

    Our research explores how transcription initiation is regulated across different RNA polymerases. We focus on the TATA-box binding protein (TBP) and its role in transcription initiation for RNA Polymerases I, II, and III. We are particularly interested in understanding TBP-independent mechanisms that have emerged in multicellular organisms and how these alternative pathways influence gene regulation during development and stress responses.

    Mechanisms of Transcriptional Memory

    We investigate how cells "remember" their transcriptional state through multiple cell divisions. Our research examines the role of transcription factors in maintaining gene expression patterns. In particular, we are interested in the role of TFs like Sox2 as mitotic bookmarks and how this contributes to transcriptional memory in mammalian embryonic stem cells.

    Evolutionary Forces Driving Conservation vs. Diversification in Transcription

    Our work explores the evolutionary pressures that shape transcriptional machinery. We examine the divergence of Transcription factors across species and how these changes have influenced transcriptional regulation. By combining evolutionary genomics with functional assays, we aim to uncover how conserved and divergent mechanisms contribute to gene regulation in complex organisms.

    Disease-Relevant Mutations in Transcription and Chromatin Proteins

    Our research investigates how mutations in key transcription factors and chromatin regulators contribute to human disease. We focus on conditions such as neurodevelopment disorders, SOXopathies, atrial fibrillation, and hypertrophic cardiomyopathy. Through stem cell models and functional genomics, we aim to understand how these mutations disrupt normal gene regulation and identify potential therapeutic targets.